Erythema Multiforme : What Is It ? Description, Management and Advice For Patient

Erythema Multiforme : What Is It ? Description, Management and Advice For Patient


Description

● Erythema multiforme, often of unknown cause, is an acute selflimiting inflammatory condition with herpes simplex virus being the main precipitating factor. Other infections and drugs are also causes. Mucosal involvement is absent or limited to only one mucosal surface.

● Stevens-Johnson syndrome is characterised by mucocutaneous necrosis with at least two mucosal sites involved. Skin involvement may be limited or extensive. Drugs or combinations of infections or drugs are the main associations. Epithelial necrosis with few inflammatory cells is seen on
histopathology. The extensive necrosis distinguishes Stevens- Johnson syndrome from erythema multiforme. Stevens-Johnson syndrome may have features overlapping with toxic epidermal
necrolysis including a prodromal illness.

● Toxic epidermal necrosis which is usually drug-induced, is an acute severe similar disease characterised by extensive skin and mucosal necrosis accompanied by systemic toxicity. On histopathology there is full thickness epidermal necrosis with subepidermal detachment.

Management

● Early recognition and call for help
● Full supportive care to maintain haemodynamic equilibrium

Complications

● Mortality rates are 5-12% with SJS and >30% with TEN with death often due to sepsis, electrolyte imbalance or multi-system organ failure

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Erythema Multiforme : What Is It ? Description, Management and Advice For Patient 2018-12-27T21:24:00-08:00 Rating: 4.5 Diposkan Oleh: David Maharoni