Pemphigus Vulgaris : Description, Treatment, Management and Advice For Patient
Description
● A blistering skin disorder which usually affects the middle-aged
Cause
● Autoantibodies against antigens within the epidermis causing an intra-epidermal split in the skin
Presentation
● Flaccid, easily ruptured blisters forming erosions and crusts
● Lesions are often painful
● Usually affects the mucosal areas (can precede skin involvement)
Management
● General measures – wound dressings where required, monitor for signs of infection, good oral care (if oral mucosa is involved)
● Oral therapies – high-dose oral steroids, immunosuppressive agents (e.g. methotrexate, azathioprine, cyclophosphamide, mycophenolate mofetil, and other)
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