Current View on the Spectrum of Contact Allergy to Important Sensitizers Across Europe

Current View on the Spectrum of Contact Allergy to Important Sensitizers Across Europe

In 1996 a European surveillance network was created to analyze routinely collected data in various contact allergy units in several European countries (European Surveillance System on Contact Allergies [ESSCA]; www.essca-dc.org). ESSCA has been fully operational since 2001, with several surveillance networks currently participating, among them the British Contact Dermatitis Group; the IVDK in Germany, Switzerland, and Austria; the Northeast Italian Contact Dermatitis Group; and, more recently, the 5 hospital dermatology departments affiliated with the Spanish Group for Research Into Contact Dermatitis and Skin Allergy/Spanish Surveillance System on Contact Allergies.

Nickel sulphate remains the most common allergen with standardized prevalences ranging from 19.7% (central Europe) to 24.4% (southern Europe). While a number of allergens shows limited variation across the four regions, such as

1. Contact allergy was independent of enhanced IgE responsiveness.
2. The median prevalence of contact allergy was 20% (adults 15–69 years).
3. Contact allergy to a wide range of allergens as well as multiple contact allergy was observed in both children and adults.
4. Contact allergy was most commonly observed against nickel, fragrances, and thimerosal.
5. The proportion of nickel allergy out of contact allergy to at least 1 allergen has been increasing significantly over the past 4 decades.
6. The median prevalence of nickel allergy among women was 17.1%.
7. A median prevalence of 81.5% women, have pierced ears.
8. Pierced ears are a strong risk factor for nickel allergy.
9. Nickel contact allergy may be associated with hand eczema in women.
10. Heavy smoking may be a risk factor for nickel allergy.

Main findings from epidemiological population-based studies (published between 1966 and 2007) investigating contact allergy in the general population or subgroups of the general population.

Myroxylon pereirae (5.3-6.8%), cobalt chloride (6.2-8.8%) or thiuram mix (1.7-2.4%), the differences observed with other allergens may hint on underlying differences in exposures, for example: dichromate 2.4% in the UK (west) versus 4.5-5.9% in the remaining EU regions, methylchloroisothiazolinone/methylisothiazolinone 4.1% in the South versus 2.1-2.7% in the remaining regions.

The continuous collection and analysis of data within multicenter clinical epidemiology offer practical findings.described main findings from epidemiological population-based studies investigating contact allergy in the general population or subgroups of the general population.

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Current View on the Spectrum of Contact Allergy to Important Sensitizers Across Europe 2018-12-30T06:49:00-08:00 Rating: 4.5 Diposkan Oleh: David Maharoni